The EquiCell system.
Regeneration. Directly on-site.

RegMed Vet utilises the clinically established methodology of adipose stem cell therapy, while consistently optimising the extraction process. The system works autologously, enzyme-free and without allogeneic stem cells. Processing is performed without centrifugation, exclusively via filtration and modern fluid mechanical separation using patent-registered 3D-printed filters. Internal laboratory tests with equine fat demonstrate a very high cell and SVF yield, at least comparable to centrifuge-based methods and frequently exceeding them. The entire process takes under five minutes and is ideally suited for point-of-care application.

An extensive body of preclinical and clinical evidence exists for the use of adipose-derived stem cells (ASCs), the stromal vascular fraction (SVF) and the associated secretome (including exosomes) in horses. In established equine osteoarthritis models, intra-articularly administered SVF and MSC preparations demonstrated significant effects on inflammatory parameters, the joint environment and clinical lameness, with very good tolerability. Clinical studies in naturally occurring degenerative joint disease (DJD) also confirm a relevant reduction in lameness, in some cases after just one to two treatments within a 90-day follow-up. Controlled experimental studies on tendon and ligament lesions additionally show improved histological fibre organisation and reduced inflammatory response following application of adipose cell fractions.

Compared to PRP or IRAP, which act primarily via growth factor- or cytokine-based mechanisms, adipose stem cells exert additional cellular and paracrine effects. These include immunomodulation, regulation of the inflammatory environment and regenerative signals via exosomes. Surgical interventions remain essential for structural defects, while adipose stem cell therapies are particularly beneficial in early to moderate stages and as an adjunctive measure postoperatively.

Treatment success is assessed using standardised lameness scores (e.g. AAEP), objective gait analysis, clinical functional evaluation and imaging procedures (ultrasound, X-ray, MRI). Studies additionally employ synovial biomarkers and histological endpoints.

The effect of adipose stem cells is predominantly based on paracrine mechanisms. The cells act in an immunomodulatory, anti-inflammatory and pro-regenerative manner. Exosomes and soluble factors play a central role, positively influencing the local tissue environment and supporting the body's own regenerative capacity.

RegMed Vet employs a multi-stage safety and quality concept. Extensive laboratory and practical testing was carried out prior to market launch. For the first veterinary practices and clinics, close scientific supervision is provided, including standardised clinical monitoring, outcome documentation and adverse event tracking.

According to the current body of evidence, there is no increased tumour risk associated with autologous, minimally manipulated adipose stem cell preparations. No treatment-related oncological adverse effects have been reported in equine studies.